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How Troglitazone’s Hepatotoxicity Changed Drug Development Forever — and Why It Still Matters Today Troglitazone (Rezulin), introduced by Warner-Lambert and later absorbed by Pfizer, was once celebrated as a breakthrough insulin-sensitizing therapy for type 2 diabetes. Within a few years, it became one of the most catastrophic toxicology failures in FDA history — linked to idiosyncratic yet sometimes fatal liver injury, multiple cases of acute liver failure, and a full U.S. market withdrawal in 2000.

According to The Hill, a widely used high-blood-pressure medication was voluntarily recalled after FDA testing identified contamination and quality issues that could pose serious risks to patients. https://thehill.com/policy/healthcare/5636604-high-blood-pressure-medication-voluntarily-recalled-fda Why do these recalls keep happening?  Because wherever chemistry, manufacturing, and patient exposure intersect — toxicology decides the outcome. Here’s the one idea you should take away:

Two of the major risk factors for heart disease are high blood pressure and high blood cholesterol. If either of these numbers is high, work with your doctor to get it to a healthy range.

The University of Arizona Health Sciences recently reported that cannabis terpenes themselves — not just cannabinoids — may provide measurable pain relief and contribute to the “entourage effect.”