Blog
December 17, 2025
How QT Prolongation, hERG Blockade, and Drug Interactions Forced a Regulatory Reset In the late 1990s, two blockbuster “non-sedating” antihistamines—terfenadine (Seldane) and astemizole—were pulled from the market after being linked to QT interval prolongation and torsades de pointes, a rare but often fatal heart rhythm disturbance.
December 16, 2025
How Muscle Toxicity, Drug Interactions, and Design Blind Spots Led to a Global Withdrawal In 2001, Bayer withdrew cerivastatin—marketed as Baycol in the U.S. and Lipobay internationally—after mounting reports of rhabdomyolysis, a severe form of muscle breakdown that can lead to acute renal failure and death. The consequences were immediate and severe: a global recall, thousands of adverse event reports, over 50 confirmed deaths, multibillion-dollar litigation settlements, and long-term reputational damage that weighed heavily on Bayer’s valuation for years.
December 15, 2025
The FDA has announced a nationwide recall of a widely used over-the-counter nasal spray after testing revealed contamination with pathogenic bacteria capable of causing serious infections. […]
December 12, 2025
To diagnose a circadian rhythm disorder, your doctor may review your medical history; ask about your symptoms, sleep patterns, and environment; do a physical exam; and order diagnostic tests.
